Description

1-tert-Butyl L-Glutamate is a protected amino acid derivative of L-glutamic acid, where the tert-butyl group safeguards the γ-carboxylic acid functionality. This compound is a crucial chiral building block in the synthesis of complex peptides, pharmaceuticals, and fine chemicals, enabling selective reactions and improved solubility in organic media. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for developing active pharmaceutical ingredients (APIs) and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs, prodrugs, and other therapeutic agents.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected glutamic acid residue to prevent side reactions.
• Bioconjugation & Linker Chemistry: Serves as a spacer or linker molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Agrochemical Research: Employed in creating novel, bioactive compounds for crop protection and agricultural chemistry.
• Biochemical Research: Used as a standard or reagent in enzymatic studies and metabolic pathway research.
• Fine Chemical Synthesis: A versatile intermediate for synthesizing complex organic molecules and specialty chemicals.

Basic Information

Product Name	1-tert-Butyl L-Glutamate
CAS No.	25456-75-1
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	L-Glutamic acid 1-tert-butyl ester; (S)-2-Amino-5-tert-butoxy-5-oxopentanoic acid; H-Glu(OtBu)-OH; N-tert-Butyloxycarbonyl-L-glutamic acid (common misnomer for related compound); tert-Butyl L-glutamate; Boc-L-Glu-OH (common misnomer); Glutamic acid, N-(1,1-dimethylethyl)-, (S)-; (S)-5-tert-Butoxy-4-carboxy-5-oxopentanoic acid
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl L-Glutamate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.