Description

Fibrinopeptide A, Human is a specific proteolytic cleavage product released from the Aα-chain of fibrinogen by the action of thrombin during the blood coagulation cascade. This peptide serves as a critical biochemical marker for in vivo thrombin generation and fibrin formation. It is primarily utilized in life science research, clinical diagnostics, and the development of hemostasis assays. Researchers and diagnostic manufacturers rely on this high-purity reference standard to study thrombosis, monitor anticoagulant therapies, and ensure the accuracy of diagnostic kits.

Application

• Biomarker Research: Used as a specific and sensitive marker for detecting and quantifying thrombin activity and fibrin formation in plasma samples.
• Clinical Diagnostics: Serves as a reference standard in immunoassays (e.g., ELISA) for measuring Fibrinopeptide A levels to diagnose and monitor thrombotic disorders.
• Anticoagulant Drug Development: Employed in pharmacological studies to evaluate the efficacy of new antithrombotic and anticoagulant agents.
• Hemostasis Assay Calibration: Essential for calibrating and validating in-vitro diagnostic (IVD) devices and kits designed to assess coagulation pathways.
• Biochemical Research: Used to study the kinetics and mechanisms of the fibrinogen-to-fibrin conversion and related enzymatic processes.
• Quality Control in IVD Manufacturing: Acts as a critical quality control component in the production of diagnostic reagents for hemostasis testing.

Basic Information

Product Name	Fibrinopeptide A, Human
CAS No.	25422-31-5
Molecular Formula	C92H123N25O27S2
Molecular Weight	2098.2 g/mol
Synonyms	Fibrinopeptide A; FPA; FpA; Human Fibrinopeptide A; Fibrinogen Alpha Chain Peptide; Thrombin-cleaved Fibrinogen Peptide A; Fibrin I Peptide; FPA (1-16); Aα 1-16 Fibrinopeptide; Fibrinopeptide A (Human); H-FPA
EINECS	Contact for details

Quality Control

Our Fibrinopeptide A, Human is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing the purity, peptide content, and results of all specified tests to ensure it meets the stringent requirements for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content (AAA)	≥ 80%
Solubility	Soluble in water or dilute acetic acid
Single Peak on HPLC	Present
Water Content (Karl Fischer)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.