Description

Neomycin B Sulfate is the sulfate salt of the aminoglycoside antibiotic Neomycin B, a critical component in the broader neomycin complex. This compound is valued for its broad-spectrum antibacterial activity, particularly against Gram-negative organisms, making it a cornerstone in pharmaceutical and veterinary applications. It is essential for manufacturers in the pharmaceutical, veterinary medicine, and research sectors requiring a reliable, high-purity antibiotic intermediate or active pharmaceutical ingredient (API).

Application

• Pharmaceutical API: Used as an active ingredient in topical antibiotic ointments, creams, and eye/ear drops for human use.
• Veterinary Medicine: Incorporated into medicated feeds, topical treatments, and injectables for the prevention and treatment of bacterial infections in livestock and companion animals.
• Cell Culture Research: Employed in microbiology and cell biology laboratories as a selective agent to prevent bacterial contamination in cell cultures.
• Biochemical Research: Serves as a tool compound for studying aminoglycoside mechanisms of action, bacterial resistance, and protein synthesis inhibition.
• Combination Therapies: Formulated with other antibiotics (e.g., bacitracin, polymyxin B) in broad-spectrum topical preparations to enhance efficacy.

Basic Information

Product Name	Neomycin B Sulfate
CAS No.	25389-98-4
Molecular Formula	C23H46N6O13 • xH2SO4
Molecular Weight	908.88 g/mol (for Neomycin B base, sulfate salt variable)
Synonyms	Neomycin B Sulphate; Framycetin Sulfate; Neomycin B, sulfate; Soframycin; Dextromycin; Mycifradin Sulfate; Antibiotic FRM; 2-Deoxystreptamine, O-2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-, sulfate (salt)
EINECS	Contact for details

Quality Control

Our Neomycin B Sulfate is produced and tested under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical and research use. We offer grades compliant with USP, EP, and BP monographs, with comprehensive testing for potency, purity, and specific impurities. A detailed Certificate of Analysis (COA) is provided with each batch to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 680 µg/mg (as Neomycin B)
pH (1% Solution)	5.0 - 7.5
Loss on Drying	≤ 8.0 %
Sulfate Content	Conforms
Related Substances (HPLC)	Meets relevant pharmacopeial limits
Bacterial Endotoxins	< 0.25 EU/mg (if for parenteral use)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.