Description

Poly-o-Acetyl-L-Hydroxyproline is a chemically modified derivative of the amino acid L-hydroxyproline, where the hydroxyl group is protected by an acetyl moiety. This modification enhances its stability and solubility in organic solvents, making it a valuable intermediate in sophisticated organic synthesis and peptide research. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in the development of novel therapeutic agents and biomaterials.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex peptide-based drugs, collagenase inhibitors, and other bioactive molecules.
• Peptide Chemistry Research: Used in solid-phase and solution-phase peptide synthesis as a protected form of hydroxyproline to study collagen-like peptides and structural biology.
• Bioconjugation & Linker Chemistry: Serves as a functionalized spacer or linker in the development of antibody-drug conjugates (ADCs) and targeted drug delivery systems.
• Cosmetic & Dermatological Actives: Incorporated into advanced formulations aimed at skin regeneration and anti-aging products due to its relation to collagen structure.
• Biomaterial Engineering: Employed in the design and synthesis of novel hydrogels, scaffolds, and biocompatible polymers for tissue engineering applications.
• Chemical Biology Probes: Acts as a precursor for creating labeled analogs and probes to study enzymatic processes involving proline and hydroxyproline metabolism.

Basic Information

Product Name	Poly-o-Acetyl-L-Hydroxyproline
CAS No.	25323-55-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-Acetyl-L-hydroxyproline; O-Acetyl-L-hydroxyproline; Ac-Hyp-OH; L-Hydroxyproline, O-acetate; (2S,4R)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid; Poly(O-acetyl-L-hydroxyproline); Poly(acetylhydroxyproline); Protected L-Hydroxyproline
EINECS	Contact for details

Quality Control

Our Poly-o-Acetyl-L-Hydroxyproline is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Standard quality parameters include identity confirmation, assay (purity), and control of specific impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.