Description

Poly-L-Leucine is a synthetic homopolymer of the essential amino acid L-leucine, known for its unique structural and self-assembly properties. This material is valued for its ability to form stable, well-defined nanostructures and its role as a model system in peptide and polymer research. It serves as a critical raw material and research reagent for scientists and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors, where precise molecular architecture is paramount.

Application

• Biomedical Research: Used as a model polypeptide for studying protein folding, aggregation, and amyloid formation.
• Drug Delivery Systems: A component in the design of biodegradable polymeric carriers and nanoparticles for controlled drug release.
• Biomaterial Fabrication: Serves as a building block for creating hydrogels, scaffolds, and coatings with tailored surface properties.
• Enzyme Mimics & Catalysis: Investigated for creating synthetic enzymes and catalytic nanostructures due to its self-assembling nature.
• Surface Modification: Employed to modify material surfaces to control cell adhesion, protein adsorption, and biocompatibility.
• Standards & Calibration: Acts as a molecular weight standard in analytical techniques like gel permeation chromatography (GPC).

Basic Information

Product Name	Poly-L-Leucine
CAS No.	25322-63-8
Molecular Formula	(C6H11NO)n
Molecular Weight	Varies by chain length (n). Contact for details.
Synonyms	Poly(leucine); L-Leucine homopolymer; PLL; Poly(Leu); Poly-L-leucine; Poly(α-L-leucine); Poly[(S)-2-amino-4-methylpentanoic acid]; Leucine polymer
EINECS	Contact for details

Quality Control

Our Poly-L-Leucine is produced under controlled conditions to ensure batch-to-batch consistency. Quality is verified through a suite of analytical methods, including determination of molecular weight distribution, amino acid analysis, and assessment of chiral purity. A Certificate of Analysis (COA) detailing specific results for each lot is provided, ensuring it meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms
Assay (Amino Acid Analysis)	≥ 95.0% (as L-Leucine)
Molecular Weight (Average)	As per customer requirement (e.g., 1kDa - 20kDa)
Optical Rotation	Specific range provided per grade
Loss on Drying	≤ 5.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.