Description

Poly-L-Hydroxyproline is a high-purity, synthetic polypeptide derived from the amino acid hydroxyproline. This specialized biomaterial is valued for its unique structural properties and high biocompatibility, making it a critical component in advanced biomedical and cosmetic research. It is essential for manufacturers and R&D teams in the pharmaceutical, biomaterials, and high-end personal care industries seeking reliable, high-quality raw materials for innovative applications.

Application

• Biomedical Research & Tissue Engineering: As a key structural mimic of collagen, it is used in scaffolds for cell culture, wound healing matrices, and 3D bioprinting applications.
• Cosmetic & Skincare Formulations: Serves as a bioactive peptide in anti-aging serums, moisturizers, and creams for its purported skin-repair and hydration properties.
• Pharmaceutical Development: Employed in drug delivery systems, including hydrogels and microparticles, for controlled release of active pharmaceutical ingredients (APIs).
• Biochemical & Enzymology Studies: Used as a substrate or standard in enzymatic assays and studies related to collagen metabolism and proline hydroxylase activity.
• Nutraceuticals: Investigated for potential use in dietary supplements targeting joint and connective tissue health.
• Reference Standard: Acts as a high-purity analytical standard in quality control laboratories for chromatography and spectroscopy.

Basic Information

Product Name	Poly-L-Hydroxyproline
CAS No.	25249-07-4
Molecular Formula	(C5H9NO3)n
Molecular Weight	Varies by polymer chain length (n)
Synonyms	Poly(4-hydroxy-L-proline); Poly(hydroxyproline); Poly(L-4-hydroxyproline); Poly(trans-4-hydroxy-L-proline); L-Hydroxyproline homopolymer; (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid homopolymer; Collagen-model polypeptide; HYP Polymer
EINECS	Contact for details

Quality Control

Our Poly-L-Hydroxyproline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and polymer distribution analysis, FT-IR for structural identification, and specific tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0% (as Poly-L-Hydroxyproline)
Molecular Weight Range	1,000 - 10,000 Da (Custom ranges available)
Loss on Drying	≤ 5.0 %
Residue on Ignition	≤ 0.5 %
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.