Description

Polyleucine is a synthetic polymer composed of repeating leucine amino acid units, offering a unique combination of biocompatibility and hydrophobic character. This material is valued for its ability to form stable, self-assembled structures and its utility as a model compound for studying protein folding and aggregation. It serves as a critical raw material and research tool for scientists and manufacturers in the pharmaceutical and advanced materials sectors. The product is available under CAS No. 25248-98-0 to ensure precise identification and sourcing.

Application

• Pharmaceutical Research: Used as a model peptide for studying amyloid formation, protein aggregation kinetics, and neurodegenerative disease mechanisms.
• Biomaterial Fabrication: Serves as a hydrophobic block in the synthesis of amphiphilic copolymers for drug delivery systems, such as micelles and nanoparticles.
• Cosmetic Science: Incorporated into formulations for its film-forming and moisture-binding properties, enhancing product texture and skin feel.
• Surface Modification: Applied as a coating to impart hydrophobicity and biocompatibility to medical devices and implants.
• Catalyst Support: Utilized as a chiral scaffold or support material in asymmetric synthesis and heterogeneous catalysis.
• Reference Standard: Acts as a calibration standard in chromatographic and spectroscopic analysis within quality control laboratories.

Basic Information

Item	Detail
Product Name	Polyleucine
CAS No.	25248-98-0
Molecular Formula	(C6H11NO)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(L-leucine); Poly(leucine); L-Leucine Homopolymer; Leucine Polymer; Poly-Leu; PL; PLeu; (S)-Poly(1-carboxy-4-methylpentylamine)
EINECS	Contact for details

Quality Control

Our Polyleucine is produced under a rigorous quality management system. Each batch is characterized to ensure consistent molecular weight distribution, enantiomeric purity (for chiral forms), and chemical structure. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as assay, residual solvents, and endotoxin levels where applicable, supporting its use in research and GMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term stability, consider storage under an inert atmosphere or with desiccant.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (Amino Acid Analysis)	≥ 95.0%
Molecular Weight (Average)	As per customer grade (e.g., 1kDa - 20kDa)
Moisture Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.