Description

Polyarginine CAS NO 25212-18-4 is a cationic biopolymer composed of multiple arginine amino acid residues, known for its strong positive charge and cell-penetrating properties. This unique structure makes it a highly effective tool for enhancing the delivery of bioactive molecules across cellular membranes. It is essential for researchers and formulators in the pharmaceutical, biotechnology, and cosmetic industries seeking to improve the bioavailability and efficacy of their products.

Application

• Drug Delivery Systems: As a cell-penetrating peptide (CPP) to facilitate the intracellular delivery of therapeutic agents, including nucleic acids (DNA, siRNA), proteins, and small molecule drugs.
• Cosmetic & Skincare Formulations: Used in anti-aging and moisturizing products for its skin-penetration enhancement properties, helping active ingredients like vitamins and peptides reach deeper skin layers.
• Biomaterial & Tissue Engineering: Serves as a coating or component in scaffolds to promote cell adhesion, proliferation, and differentiation due to its positive charge interacting with negatively charged cell membranes.
• Antimicrobial Coatings: Incorporated into surface coatings for medical devices or packaging materials, leveraging its cationic nature to disrupt microbial cell walls.
• Gene Therapy Research: A key non-viral vector for condensing and delivering genetic material into cells for research and potential therapeutic applications.
• Diagnostic Agent Carrier: Enhances the cellular uptake of imaging agents and contrast media for improved diagnostic accuracy.

Basic Information

Product Name	Polyarginine
CAS No.	25212-18-4
Molecular Formula	(C6H14N4O2)n • xHCl
Molecular Weight	Variable (based on chain length 'n')
Synonyms	Poly(L-arginine); L-Arginine Homopolymer; Arg(n); Poly-Arg; Cationic Polypeptide; Cell-Penetrating Peptide (CPP) Rn; Polyarginine Hydrochloride; Oligoarginine
EINECS	Contact for details

Quality Control

Our Polyarginine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing key parameters such as degree of polymerization, purity by HPLC, chloride content, and endotoxin levels where applicable. Our quality commitment supports applications requiring high standards, including research and cGMP-guided development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (Purity)	≥ 95% (by HPLC)
Degree of Polymerization (n)	Specified range (e.g., 5-50)
Chloride Content	As per theoretical (for hydrochloride form)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Endotoxin (where applicable)	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.