Description

Poly-L-Alanine CAS NO 25191-17-7 is a synthetic homopolymer of the amino acid L-alanine, known for its structural simplicity and utility as a model compound in biochemical research. This polypeptide is valued for its role in studying protein folding, secondary structure formation, and as a calibration standard in analytical chemistry. It is an essential material for research institutions, pharmaceutical developers, and manufacturers in the life sciences sector requiring high-purity biochemical tools.

Application

• Biochemical Research: Used as a model polypeptide for studying α-helix formation, protein folding kinetics, and peptide stability.
• Analytical Standard: Serves as a critical calibration standard in chromatography (HPLC, GPC) and mass spectrometry for molecular weight determination and method validation.
• Pharmaceutical Development: Employed in pre-formulation studies and as a component in the development of drug delivery systems and biomaterials.
• Material Science: Investigated for creating bio-inspired polymers, hydrogels, and surface coatings due to its self-assembly properties.
• Enzyme Substrate: Acts as a substrate for proteolytic enzymes in enzyme activity assays and mechanistic studies.
• Education: Used in academic laboratories for teaching advanced concepts in polymer chemistry and biochemistry.

Basic Information

Product Name	Poly-L-Alanine
CAS No.	25191-17-7
Molecular Formula	(C3H7NO2)n
Molecular Weight	Varies by chain length (n). Contact for details on specific molecular weight grades.
Synonyms	Poly(alanine); Poly-L-alanine; L-Alanine homopolymer; PAla; PLA; Poly(Ala); Poly(alanine) homopolymer; (S)-Polyalanine; Poly-α-L-alanine
EINECS	Contact for details

Quality Control

Our Poly-L-Alanine is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Quality is verified through a suite of analytical techniques including HPLC, NMR, and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, molecular weight distribution, and other critical parameters is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95% (Poly-L-Alanine content)
Molecular Weight (GPC)	As per customer requirement (e.g., 1kDa - 20kDa)
Water Content (KF)	≤ 5.0 %
Residue on Ignition	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.