Description

Poly-L-Proline is a synthetic, high-purity homopolymer of the amino acid L-proline, widely recognized for its unique structural properties and role in biochemical research. This product is essential for studying protein folding, collagen structure, and as a molecular standard in chromatography and spectroscopy. It serves as a critical reagent for pharmaceutical R&D, academic laboratories, and biotechnology companies focused on peptide science and biomaterials. Our supply ensures consistent quality and reliable performance for your most demanding applications.

Application

• Biochemical Research & Standard: Used as a model compound for studying polyproline helices, protein secondary structure, and collagen mimetics.
• Pharmaceutical Development: Employed in drug discovery platforms, particularly for targeting protein-protein interactions and as a component in peptide-based therapeutics.
• Chromatography: Serves as a calibration standard for size-exclusion chromatography (SEC) and other analytical techniques to determine molecular weight distributions.
• Material Science: Investigated for creating bio-inspired materials, hydrogels, and coatings due to its rigid, rod-like structure.
• Enzyme Studies: Utilized as a substrate or inhibitor in assays for proline-specific enzymes like prolyl hydroxylase or prolyl oligopeptidase.
• Cell Culture & Scaffolds: Explored in biomedical engineering for modifying surfaces to influence cell adhesion and growth.

Basic Information

Product Name	Poly-L-Proline
CAS No.	25191-13-3
Molecular Formula	(C5H9NO2)n
Molecular Weight	Variable (based on chain length 'n')
Synonyms	Polyproline; Poly(L-proline); L-Proline homopolymer; (2S)-Pyrrolidine-2-carboxylic acid homopolymer; Poly(Pro); PPL; Polyproline I/II helix; Poly-L-proline chain; Poly(Proline)
EINECS	Contact for details

Quality Control

Our Poly-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analysis to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing key parameters such as molecular weight distribution, optical rotation, and purity by HPLC. Our quality commitment supports applications requiring research-grade to high-purity specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95% (Poly-L-Proline content)
Specific Optical Rotation	Contact for details
Molecular Weight (Average)	Specified by grade (e.g., 1,000 - 20,000 Da)
Loss on Drying	≤ 5.0 %
Residue on Ignition	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.