Description

5-Chloro-2,4-difluoropyrimidine is a high-value halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs), particularly in the agrochemical and pharmaceutical sectors. It is primarily needed by R&D chemists and process development scientists working on nucleoside analogs, kinase inhibitors, and other fine chemicals where precise fluorination and chlorination patterns are critical.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel nucleoside analogs and antiviral/anticancer drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides that require fluorinated pyrimidine cores.
• Material Science Research: Serves as a precursor for developing specialty chemicals and functional materials with tailored electronic properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity fluorinated heterocycles.

Basic Information

Product Name	5-Chloro-2,4-Difluoropyrimidine
CAS No.	25151-07-9
Molecular Formula	C4HClF2N2
Molecular Weight	150.51 g/mol
Synonyms	2,4-Difluoro-5-chloropyrimidine; 5-Chloro-2,4-difluoro-pyrimidine; Pyrimidine, 5-chloro-2,4-difluoro-; 25151-07-9; NSC 403016; 5-Chloro-2,4-difluoropyrimidine; 2,4-Difluoro-5-chloro-1,3-diazine
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,4-difluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.