Description

Poly-L-Lysine is a synthetic, cationic homopolymer of the essential amino acid L-lysine, widely recognized for its strong positive charge and biocompatibility. This unique biopolymer is crucial for applications requiring cell adhesion promotion, surface coating, and controlled drug delivery. It is an indispensable material for researchers and manufacturers in the life sciences, pharmaceutical development, and advanced material sectors. Our high-purity Poly-L-Lysine CAS NO 25104-18-1 ensures consistent performance and reliable results for critical industrial and research processes.

Application

• Cell Culture & Tissue Engineering: As a coating agent to enhance the attachment and proliferation of anchorage-dependent mammalian cells on culture surfaces.
• Biomedical Research: Used to create positively charged substrates for immobilizing DNA, proteins, and other biomolecules in microarray and biosensor fabrication.
• Drug Delivery Systems: Serves as a biodegradable carrier or conjugate in the formulation of nanoparticles and microparticles for controlled release of therapeutic agents.
• Diagnostic Assays: Employed to improve the binding efficiency of capture antibodies or antigens in ELISA and other immunoassay platforms.
• Gene Transfection: Acts as a non-viral vector to complex with and deliver nucleic acids into cells for genetic studies.
• Cosmetic Formulations: Utilized as a film-forming and conditioning agent in advanced skincare and haircare products.

Basic Information

Product Name	Poly-L-Lysine
CAS No.	25104-18-1
Molecular Formula	(C6H14N2O2)n
Molecular Weight	Varies by degree of polymerization (e.g., 30-300 kDa). Contact for details.
Synonyms	PLL; Poly(L-lysine); L-Lysine homopolymer; Polylysine; ε-Poly-L-lysine; PLL Hydrobromide (common salt form); Poly(L-lysine hydrobromide); (S)-Poly(amino(4-aminobutyl)acetic acid)
EINECS	Contact for details

Quality Control

Our Poly-L-Lysine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets precise specifications for molecular weight distribution, purity, and biological activity. Certificates of Analysis (COA) detailing key parameters such as assay, endotoxin levels, and sterility (where applicable) are provided to guarantee consistency and traceability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at 2-8°C. The product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solution
Identification (IR)	Conforms
Assay (Dry Basis)	≥ 95.0%
Molecular Weight (Average)	15-300 kDa (Specific grade available)
pH (1% solution)	6.0 - 8.0
Loss on Drying	≤ 5.0 %
Endotoxin (for cell culture grade)	< 1.0 EU/mg
Biological Activity (Cell Adhesion)	Pass

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.