Description

1-De-Asp-4-Me-Tyr-Angiotensin II is a synthetic peptide analog of the potent vasoconstrictor hormone Angiotensin II, specifically modified at the aspartic acid and tyrosine residues. This compound is a critical research tool for investigating the renin-angiotensin system (RAS), its role in blood pressure regulation, and the development of novel cardiovascular therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on endocrinology and hypertension.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of the renin-angiotensin-aldosterone system (RAAS) and its physiological effects.
• Pharmacological Studies: Serves as a key ligand in receptor binding assays and functional studies to characterize Angiotensin II receptor subtypes (AT1 and AT2).
• Drug Discovery & Development: Acts as a precursor or intermediate in the synthesis and screening of novel antihypertensive agents and receptor antagonists.
• In Vitro Diagnostics: Employed in the development and calibration of immunoassays (e.g., ELISA) for detecting and quantifying angiotensin-related peptides.
• Academic & Clinical Research: Facilitates fundamental research into cardiovascular diseases, renal function, and fluid-electrolyte balance.

Basic Information

Product Name	1-De-Asp-4-Me-Tyr-Angiotensin II
CAS No.	25061-83-0
Molecular Formula	C₄₈H₆₈N₁₂O₁₁
Molecular Weight	997.1 g/mol
Synonyms	1-De-Asp-4-Methyl-Tyrosine-Angiotensin II; [4-Me-Tyr¹]-Angiotensin II (1-8); Des-Asp¹-[Me-Tyr⁴]-Angiotensin II; Angiotensin II (1-8), 1-de-Asp-4-Me-Tyr-; Saralasin analog; [Sar¹,Me-Tyr⁴]-Angiotensin II fragment; ATII analog; Hypertensive peptide analog
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and content. Quality is assured through multiple orthogonal analytical techniques, including HPLC for purity and MS for identity confirmation, ensuring compliance with research-grade standards. We support custom synthesis to meet specific purity and packaging requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.