Description

Angiotensin II, Des-Asp(1)-Me-Tyr(4)- is a synthetic peptide analog of angiotensin II, a key regulator of blood pressure and fluid balance. This modified peptide is of significant value for research into the renin-angiotensin system (RAS), receptor binding studies, and the development of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cardiovascular and renal disease research. The compound is supplied with a high level of purity to ensure reliable and reproducible experimental results.

Application

• Biochemical Research: Used as a reference standard and tool compound in studies of the renin-angiotensin system (RAS) and its physiological effects.
• Receptor Pharmacology: Employed in in vitro and in vivo assays to investigate angiotensin II receptor (AT1/AT2) binding, activation, and downstream signaling pathways.
• Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the preclinical development of cardiovascular and antihypertensive therapeutics.
• Academic Studies: Utilized in university and institutional labs for fundamental research on blood pressure regulation, vascular biology, and kidney function.
• Diagnostic Development: Potential use in the development of diagnostic assays and kits related to cardiovascular health markers.

Basic Information

Product Name	Angiotensin II, Des-Asp(1)-Me-Tyr(4)-
CAS No.	25061-69-2
Molecular Formula	C₄₈H₆₈N₁₂O₁₂
Molecular Weight	1029.2 g/mol
Synonyms	Des-Asp1-Me-Tyr4-Angiotensin II; [Me-Tyr4]-Angiotensin II (1-8); [Sar1, Me-Tyr4]-Angiotensin II (fragment 1-8); Angiotensin II (1-8), 1-Asparagine-4-(methyl-L-tyrosine)-; H-Asp-Arg-Val-Tyr(Me)-Ile-His-Pro-Phe-OH; (Me)Tyr4-Angiotensin II; [MeTyr4]-Ang II
EINECS	Contact for details

Quality Control

Our Angiotensin II, Des-Asp(1)-Me-Tyr(4)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.