Description

2-[(Difluoromethyl)Thio]Aniline Hydrochloride is a specialized organic intermediate featuring a difluoromethylthio (-SCF2H) substituent, a motif of significant interest in modern medicinal and agrochemical chemistry. This compound matters as a key building block for introducing the unique physicochemical properties of fluorine into target molecules, enhancing metabolic stability, lipophilicity, and bioavailability. It is primarily needed by R&D and process development teams in the pharmaceutical and crop protection industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics where the difluoromethylthio group modulates biological activity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the fluorine-containing moiety can improve environmental stability and target specificity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced materials with tailored surface properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and labeled compounds for studying biochemical pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific projects requiring this unique fluorinated aniline derivative.

Basic Information

Product Name	2-[(Difluoromethyl)Thio]Aniline Hydrochloride
CAS No.	24933-58-2
Molecular Formula	C7H8ClF2NS
Molecular Weight	211.66 g/mol
Synonyms	2-(Difluoromethylthio)aniline hydrochloride; 2-Amino-α,α-difluorobenzyl mercaptan hydrochloride; Benzenamine, 2-[(difluoromethyl)thio]-, hydrochloride; 2-(Difluoromethylsulfanyl)aniline hydrochloride; 2-SCF2H-Aniline HCl; 2-Amino-α,α-difluorothioanisole hydrochloride; 2-[(Difluoromethyl)sulfanyl]benzenamine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-[(Difluoromethyl)Thio]Aniline Hydrochloride is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.