Description

n-Methyl-L-Histidine is a naturally occurring, modified amino acid derivative of L-histidine, characterized by the methylation of the imidazole nitrogen. This specific structural modification is of significant interest in biochemical research and pharmaceutical development, particularly in the study of protein methylation and metabolic pathways. It serves as a critical reference standard, intermediate, and research chemical for scientists and manufacturers in the life sciences sector.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of methylated histidine derivatives in drug development and quality control.
• Biochemical Research: Essential for studying enzymatic methylation processes, protein post-translational modifications, and related metabolic functions.
• Metabolite Analysis: Acts as a key biomarker or standard in metabolomics studies and clinical research for diagnosing certain metabolic disorders.
• Peptide Synthesis: Employed as a specialized building block for the synthesis of modified peptides with specific biological activities.
• Nutritional Science Research: Investigated for its role and presence in dietary proteins and its potential physiological effects.
• Diagnostic Reagent Manufacturing: Utilized in the production of diagnostic kits and assays for detecting specific metabolic markers.

Basic Information

Product Name	n-Methyl-L-Histidine
CAS No.	24886-03-1
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	1-Methyl-L-histidine; L-1-Methylhistidine; (2S)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid; Hercynine; Thioneine; Tele-methylhistidine; Nτ-Methyl-L-histidine; Nπ-Methyl-L-histidine
EINECS	Contact for details

Quality Control

We supply n-Methyl-L-Histidine in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We can support projects requiring material that aligns with cGMP principles for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Specific range available on COA
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.