Description

H-Gly-Trp-Gly-Gly-OH is a high-purity tetrapeptide sequence containing the essential amino acid tryptophan. This compound is valued for its role as a key intermediate in advanced peptide synthesis and biochemical research. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on neuropeptide studies, drug discovery, and the development of bioactive peptide conjugates.

Application

• Pharmaceutical Research & Development: Serves as a critical building block (intermediate) in the synthesis of complex therapeutic peptides targeting neurological and metabolic pathways.
• Biochemical Assay Development: Used as a standard or substrate in enzymatic studies and receptor-ligand binding assays due to its specific amino acid sequence.
• Neuropeptide Analog Synthesis: Acts as a core structure for developing analogs to study sleep, mood, and appetite regulation, leveraging the properties of the tryptophan residue.
• Cosmeceutical Peptide Design: Incorporated into the design of novel peptide sequences for potential skincare applications targeting skin barrier function and antioxidant activity.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental studies in peptide chemistry, structure-activity relationships (SAR), and molecular biology.
• Process Development & Scale-Up: Used by CROs and CDMOs to develop and optimize scalable, GMP-compliant manufacturing processes for peptide-based Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	H-Gly-Trp-Gly-Gly-OH
CAS No.	24591-52-4
Molecular Formula	C19H24N6O5
Molecular Weight	416.43 g/mol
Synonyms	Glycyl-L-tryptophylglycylglycine; G-W-G-G-OH; H-Gly-Trp-Gly-Gly; Tetrapeptide Gly-Trp-Gly-Gly; L-Tryptophan, glycyl-L-tryptophylglycylglycine; Gly-Tryptophan-Gly-Gly; GWGG; Tryptophan-containing tetrapeptide
EINECS	Contact for details

Quality Control

Our H-Gly-Trp-Gly-Gly-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Assay (Content)	≥ 95.0% (on anhydrous basis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.