Description

H-Phe-Trp-Oh is a high-purity dipeptide building block, specifically the C-terminal carboxylic acid derivative of the phenylalanine-tryptophan sequence. This compound is essential for advanced peptide synthesis and pharmaceutical research, offering precise structural control for developing novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide-based drug discovery, medicinal chemistry, and biochemical studies.

Application

• Pharmaceutical Intermediate: A key building block for the solid-phase and solution-phase synthesis of complex therapeutic peptides.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new drug candidates targeting various receptors.
• Biochemical Probe Development: Serves as a precursor for labeled peptides used in enzyme assays and cellular signaling pathway analysis.
• Cosmeceutical Peptide Synthesis: Incorporated into the design of anti-aging and skin-repair peptide sequences for advanced cosmetic formulations.
• Academic Research: Employed in university and institutional labs for studying peptide folding, stability, and molecular interactions.

Basic Information

Product Name	H-Phe-Trp-Oh
CAS No.	24587-41-5
Molecular Formula	C20H21N3O3
Molecular Weight	351.40 g/mol
Synonyms	L-Phenylalanyl-L-tryptophan; Phe-Trp; F-W-OH; H-Phe-Trp-OH; Phenylalanine Tryptophan; N-[(2S)-1-[[(2S)-1-Hydroxy-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-phenyl-1-oxopropan-2-yl]carbamic acid; FMOC-Phe-Trp-OH (precursor form); Z-Phe-Trp-OH (precursor form)
EINECS	Contact for details

Quality Control

Our H-Phe-Trp-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and residual solvent screening. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	-20° to -25° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.