Description

Ethyl 3-Chlorotetrafluoropropionate is a specialized fluorinated organic ester with the CAS registry number 24482-88-0. This compound is valued for its role as a versatile fluorinated building block in advanced chemical synthesis, offering unique reactivity due to the combination of chlorine and fluorine substituents. It is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the tetrafluoroethyl moiety into potential drug candidates, particularly in medicinal chemistry for metabolic stability enhancement.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where fluorination improves biological activity and environmental persistence.
• Fluorinated Polymer & Material Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers with enhanced chemical resistance, thermal stability, and low surface energy properties.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and coupling reactions to construct complex fluorinated architectures in fine chemical manufacturing.
• Liquid Crystal & Electronic Chemical: Potential application in the synthesis of fluorinated components for liquid crystal displays (LCDs) and dielectric materials.

Basic Information

Product Name	Ethyl 3-Chlorotetrafluoropropionate
CAS No.	24482-88-0
Molecular Formula	C5H5ClF4O2
Molecular Weight	208.54 g/mol
Synonyms	3-Chlorotetrafluoropropionic Acid Ethyl Ester; Ethyl 3-Chloro-2,2,3,3-tetrafluoropropionate; 2,2,3,3-Tetrafluoro-3-chloropropionic Acid Ethyl Ester; Ethyl α-Chloro-β,β,β-trifluoropropionate (related); ECTFP; Propanoyl chloride, 3-chloro-2,2,3,3-tetrafluoro-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 3-Chlorotetrafluoropropionate is manufactured under strict process controls to ensure batch-to-batch consistency and high purity, typically ≥98% (GC). Quality is verified through a comprehensive suite of analytical methods including Gas Chromatography (GC), NMR, and FTIR. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and fluorides. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	~1.45 g/mL
Refractive Index (n20D)	~1.35

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.