Description

o-[4-Hydroxy-3-(125I)Iodophenyl]-3,5-Di(125I)Iodo-L-Tyrosine is a high-specific-activity, radioiodinated derivative of the amino acid L-tyrosine, designed for advanced research and diagnostic applications. This compound is critical for developing highly sensitive and specific radiopharmaceuticals and radioligands used in molecular imaging and biochemical assays. It is primarily utilized by pharmaceutical R&D teams, radiochemistry laboratories, and diagnostic imaging centers engaged in cutting-edge work with thyroid hormone analogs, receptor binding studies, and targeted radionuclide therapy research.

Application

• Radiopharmaceutical Precursor: Serves as a key intermediate in the synthesis of novel iodine-125 labeled diagnostic agents for SPECT imaging.
• Receptor Binding Assays: Used as a high-affinity radioligand in competitive binding studies for receptors that recognize tyrosine-based structures, such as certain hormone receptors.
• Metabolic Pathway Tracing: Enables the study of tyrosine metabolism and iodothyronine biosynthesis pathways in experimental models.
• Thyroid Research: Acts as a sophisticated tool for investigating thyroid hormone synthesis, transport, and deiodination mechanisms at a molecular level.
• Antibody & Peptide Radiolabeling: Provides a route for site-specific radioiodination of monoclonal antibodies and bioactive peptides for targeted therapy and immunoassays.
• Quality Control Reference Standard: Employed as an analytical reference standard in the quality control of other iodinated tyrosine derivatives and related pharmaceuticals.

Basic Information

Item	Details
Product Name	o-[4-Hydroxy-3-(125I)Iodophenyl]-3,5-Di(125I)Iodo-L-Tyrosine
CAS No.	24359-14-6
Molecular Formula	C15H10125I3NO4
Molecular Weight	Contact for details
Synonyms	3,5-Diiodo-L-tyrosine, [125I]-labeled; L-Tyrosine, o-[4-hydroxy-3-(125I)iodophenyl]-3,5-di(125I)iodo-; Radioiodinated 3,5-Diiodo-L-tyrosine; [125I]DIT; 125I-Labeled DIT; (125I)Iodotyrosine derivative; Precursor for thyroid hormone analogs
EINECS	Contact for details

Quality Control

Every batch of our o-[4-Hydroxy-3-(125I)Iodophenyl]-3,5-Di(125I)Iodo-L-Tyrosine is manufactured and controlled under a strict quality management system. Radiochemical purity and specific activity are determined via validated analytical methods such as radio-HPLC and gamma counting to ensure consistency and performance for research use. A comprehensive Certificate of Analysis (COA) detailing radionuclidic purity, radiochemical purity, specific activity, and solvent content is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. This material is strictly light-sensitive (protect from all light exposure). Store at or below -20°C in the original lead-shielded container. The storage area must be designated for radioactive materials and comply with all local and international regulations for handling radioisotopes.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Retention time corresponds to reference standard
Radiochemical Purity (Radiometric HPLC)	≥ 95%
Specific Activity	Contact for details
Radionuclidic Purity	≥ 99% Iodine-125
Solvent	Ethanol/Water or as specified
pH	3.0 - 7.0 (as supplied)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.