Description

4-Amino-L-Phenylalanine Hydrochloride Hemihydrate is a high-purity, non-natural amino acid derivative used as a critical building block in advanced chemical synthesis. This compound matters for its role as a key chiral intermediate in the development of novel pharmaceuticals and bioactive peptides. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery and development.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly for targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a para-aminophenylalanine residue, modifying peptide properties.
• Bioconjugation & Linker Chemistry: The aromatic amine group serves as a handle for conjugation with other molecules, such as dyes, drugs, or polymers, for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Chemical Biology Research: Employed as a tool compound to study enzyme mechanisms or to create labeled analogs of biological molecules.
• Material Science: Potential monomer for synthesizing specialized polymers with unique optical or electronic properties.

Basic Information

Product Name	4-Amino-L-Phenylalanine Hydrochloride Hemihydrate
CAS No.	24286-13-3
Molecular Formula	C9H12N2O2 • HCl • ½H2O
Molecular Weight	233.67 g/mol (Anhydrous HCl salt basis)
Synonyms	L-4-Aminophenylalanine hydrochloride hemihydrate; (S)-2-Amino-3-(4-aminophenyl)propanoic acid hydrochloride hemihydrate; p-Amino-L-phenylalanine HCl hemihydrate; 4-Amino-L-Phe-OH • HCl • ½H2O; Fmoc-4-Amino-L-Phenylalanine precursor; 4-NH2-Phe-OH • HCl
EINECS	Contact for details

Quality Control

Our 4-Amino-L-Phenylalanine Hydrochloride Hemihydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	3.0 - 5.0% (Theoretical for hemihydrate: ~3.85%)
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.