Description

2-Chloro-5-(Trifluoromethyl)Pyrimidin-4-Amine is a high-purity, multi-functional pyrimidine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoromethyl substituents, makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and kinase inhibitor research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances biological activity and stability.
• Material Science Research: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes, enzyme inhibitors, and labeling reagents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-fidelity halogenated pyrimidines.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Pyrimidin-4-Amine
CAS No.	24101-09-5
Molecular Formula	C5H3ClF3N3
Molecular Weight	197.55 g/mol
Synonyms	4-Amino-2-chloro-5-(trifluoromethyl)pyrimidine; 2-Chloro-5-trifluoromethyl-4-pyrimidinamine; 2-Chloro-5-(trifluoromethyl)-4-pyrimidinamine; 4-Pyrimidinamine, 2-chloro-5-(trifluoromethyl)-; 2-Chloro-5-(trifluoromethyl)pyrimidin-4-ylamine; 2-Chloro-5-trifluoromethylpyrimidin-4-amine; 24101-09-5
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Trifluoromethyl)Pyrimidin-4-Amine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.