Description

H-Ala-Thr-Oh is a protected dipeptide building block, specifically L-Alanine-L-Threonine, where the C-terminal carboxylic acid is protected as a tert-butyl ester. This compound is a critical intermediate in the synthesis of complex peptides and peptidomimetics, offering precise control over sequence and stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, development of bioactive peptides, and proteomics research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the sequential assembly of custom peptide sequences in both research and GMP manufacturing.
• Pharmaceutical Intermediates: Serves as a key precursor in the synthesis of therapeutic peptides targeting metabolic disorders, hormonal regulation, and antimicrobial applications.
• Bioconjugation & Labeling: Used to introduce specific amino acid sequences into proteins, antibodies, or other biomolecules for diagnostic or therapeutic purposes.
• Proteomics & Biochemical Research: Essential for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Cosmetic & Dermatological Peptides: A potential ingredient in the synthesis of bioactive peptides for anti-aging, moisturizing, or skin-repair formulations.

Basic Information

Product Name	H-Ala-Thr-Oh
CAS No.	24032-50-6
Molecular Formula	C11H22N2O5
Molecular Weight	262.30 g/mol
Synonyms	L-Alanyl-L-threonine tert-butyl ester; H-Ala-Thr-OtBu; Ala-Thr-OtBu; (2S,3R)-2-[[(2S)-2-Aminopropanoyl]amino]-3-hydroxybutanoic acid tert-butyl ester; tert-Butyl L-alanyl-L-threoninate; N-[(2S)-2-Aminopropanoyl]-L-threonine tert-butyl ester; Alanine, N-L-threonyl-, 1,1-dimethylethyl ester, L-; Protected Ala-Thr dipeptide
EINECS	Contact for details

Quality Control

Our H-Ala-Thr-Oh is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing specifications such as chiral purity (HPLC), assay, and residual solvent content. Our quality commitment supports applications requiring GMP-grade or high-purity research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the original container sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L,L-isomer)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.