Description

5,5,5-Trifluoronorvaline is a non-natural, fluorinated amino acid derivative characterized by a trifluoromethyl group at the terminal carbon of its side chain. This unique structure imparts enhanced metabolic stability, lipophilicity, and electronic properties, making it a valuable building block for advanced research and development. It is primarily utilized by medicinal chemists and researchers in the pharmaceutical and agrochemical industries. The compound is offered under rigorous quality control to ensure consistency for critical applications in drug discovery and material science.

Application

• Pharmaceutical Intermediate: A key synthon for incorporating fluorine into peptide-based drug candidates, potentially improving their bioavailability and binding affinity.
• Proteomics & Biochemistry Research: Used in the study of enzyme mechanisms and protein structure-function relationships as a stable, non-hydrolyzable analog.
• Agrochemical Development: Serves as a building block for novel pesticides and herbicides, where the fluorine atoms can enhance activity and environmental persistence.
• Positron Emission Tomography (PET) Tracer Synthesis: Potential precursor for 18F-labeled compounds used in medical imaging.
• Material Science: Incorporation into specialty polymers and coatings to modify surface properties and chemical resistance.
• Chemical Biology Tool: Employed to create fluorinated probes for studying biological pathways and interactions.

Basic Information

Product Name	5,5,5-Trifluoronorvaline
CAS No.	23809-57-6
Molecular Formula	C6H10F3NO2
Molecular Weight	185.14 g/mol
Synonyms	5,5,5-Trifluoro-DL-norvaline; 2-Amino-5,5,5-trifluoropentanoic acid; DL-5,5,5-Trifluoronorvaline; (RS)-5,5,5-Trifluoronorvaline; 5,5,5-Trifluoropentanoic acid, 2-amino-; Norvaline, 5,5,5-trifluoro-; 5,5,5-Trifluoronorvaline (DL-); 23809-57-6
EINECS	Contact for details

Quality Control

Our 5,5,5-Trifluoronorvaline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Optical Purity (Chiral HPLC)	DL-mixture (Contact for enantiopure grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.