Description

H-Glu-Glu-Glu-Oh is a synthetic tripeptide composed of three glutamic acid residues with a free C-terminal carboxylic acid. This compound serves as a crucial building block and model substrate in biochemical research and pharmaceutical development. It is primarily utilized by research institutions and manufacturers in the life sciences sector for applications ranging from enzyme studies to the synthesis of more complex peptide structures.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic assays, particularly for studying glutamyl-specific proteases, peptidases, and transferases.
• Pharmaceutical Intermediates: Acts as a key synthon in the solid-phase or solution-phase synthesis of longer therapeutic peptides and peptidomimetics.
• Neuroscience Studies: Employed in research related to glutamate receptors and neurotransmission due to its structural similarity to the neurotransmitter glutamate.
• Nutraceutical Development: Investigated for potential use in formulations where bioactive peptides are required, given glutamic acid's role in metabolism.
• Cosmetic Peptide Synthesis: Serves as a precursor for constructing peptides used in skincare products for moisturizing and skin barrier function.
• Material Science: Explored as a component for creating biodegradable polymers or hydrogels with specific ionic and self-assembly properties.

Basic Information

Product Name	H-Glu-Glu-Glu-Oh
CAS No.	23684-48-2
Molecular Formula	C15H23N3O9
Molecular Weight	389.36 g/mol
Synonyms	L-Glutamyl-L-glutamyl-L-glutamic acid; Tri-L-glutamic acid; (S)-2-Amino-5-((S)-2-amino-5-((S)-2-amino-5-oxopentanamido)pentanamido)pentanedioic acid; H-Glu(O)-Glu(O)-Glu(O)-OH; EEE; Glu-Glu-Glu; Glutamic acid trimer; Polyglutamic acid (trimer)
EINECS	Contact for details

Quality Control

Our H-Glu-Glu-Glu-Oh is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Optical Rotation	-30° to -35° (c=1 in H2O)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.