Description

n-Ethylsuccinimido-S-Glutathione is a chemically modified derivative of the essential cellular antioxidant glutathione. This compound matters as a key biochemical tool and synthetic intermediate, offering a reactive handle for site-specific conjugation and protein modification studies. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in drug discovery, proteomics, and the development of diagnostic assays.

Application

• Bioconjugation Reagent: Used for the site-specific labeling of proteins, peptides, and antibodies via thiol-reactive chemistry.
• Biochemical Research: Serves as a critical tool in studying glutathione metabolism, redox biology, and enzyme mechanisms.
• Pharmaceutical Intermediate: Employed in the synthesis of prodrugs and targeted therapeutic agents designed to modulate cellular redox states.
• Proteomics & Diagnostics: Facilitates the development of assay kits and diagnostic tools that rely on controlled chemical linkage.
• Antioxidant Studies: Acts as a modified substrate to investigate the function and kinetics of glutathione-related enzymes like glutathione S-transferases.

Basic Information

Product Name	n-Ethylsuccinimido-S-Glutathione
CAS No.	23559-30-0
Molecular Formula	C14H21N3O8S
Molecular Weight	391.40 g/mol
Synonyms	N-Ethylsuccinimido Glutathione; S-(N-Ethylsuccinimido)glutathione; Glutathione N-ethylsuccinimide ester; GSH-NES; γ-Glu-Cys-Gly N-ethylsuccinimide thioester; L-γ-Glutamyl-L-cysteinylglycine N-ethylsuccinimidyl ester; (2S)-2-Amino-5-[[(2R)-1-(ethoxycarbonyl)-3-[(ethylcarbamoyl)methylsulfanyl]propyl]amino]-5-oxopentanoic acid
EINECS	Contact for details

Quality Control

Our n-Ethylsuccinimido-S-Glutathione is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term stability, consider storage in a desiccator.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.