Description

Boc-Phe-Pro-Oh CAS NO 23420-32-8 is a protected dipeptide building block, specifically N-tert-Butoxycarbonyl-Phenylalanyl-Proline, widely used in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptide sequences with precise stereochemistry. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of therapeutic peptides targeting metabolic disorders, cardiovascular diseases, and oncology.
• Bioconjugation & Probe Development: Used to create labeled peptides for diagnostic imaging, fluorescence studies, and target identification in drug discovery.
• Enzyme Substrate & Inhibitor Synthesis: Serves as a precursor for developing specific substrates or inhibitors for proteases like dipeptidyl peptidase-4 (DPP-4).
• Academic & Contract Research: Essential reagent in university and CRO laboratories for fundamental peptide chemistry research and custom peptide production.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Cosmeceutical Peptide Synthesis: A component in the manufacture of bioactive peptides for advanced skincare and anti-aging formulations.

Basic Information

Product Name	Boc-Phe-Pro-Oh
CAS No.	23420-32-8
Molecular Formula	C19H26N2O5
Molecular Weight	362.42 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-phenylalanyl-L-proline; Boc-L-Phenylalanyl-L-proline; Boc-Phe-Pro-OH; (2S)-1-[(2S)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carboxylic acid; BOC-PHE-PRO; N-Boc-L-phenylalanyl-L-proline; tert-Butoxycarbonylphenylalanylproline; L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, L-prolyl-
EINECS	Contact for details

Quality Control

Our Boc-Phe-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by NMR and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-70° to -80° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.