Description

L-Propargylglycine is a non-proteinogenic amino acid derivative featuring a reactive alkyne group, making it a versatile building block in chemical synthesis and biological research. Its unique structure allows it to act as a mechanism-based inhibitor and a click chemistry handle, which is critical for developing novel pharmaceuticals and biochemical probes. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries who require high-purity intermediates for drug discovery and advanced material development.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the production of novel drug candidates, particularly enzyme inhibitors targeting metabolic pathways.
• Biochemical Research: Used as a tool compound in enzymology studies, often as an inhibitor of enzymes like cystathionine γ-lyase.
• Click Chemistry: The alkyne moiety enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and probe labeling.
• Agrochemical Development: Employed in the synthesis of advanced crop protection agents with novel modes of action.
• Peptide Modification: Incorporated into synthetic peptides to introduce unique functional groups for structural and activity studies.
• Material Science: Acts as a monomer or cross-linker precursor for creating functional polymers and smart materials.

Basic Information

Product Name	L-Propargylglycine
CAS No.	23235-01-0
Molecular Formula	C5H7NO2
Molecular Weight	113.11 g/mol
Synonyms	(S)-2-Amino-4-pentynoic acid; L-2-Amino-4-pentynoic acid; Propargylglycine; L-PPG; (S)-2-Amino-pent-4-ynoic acid; NSC 56367; 4-Pentynoic acid, 2-amino-, (S)-
EINECS	Contact for details

Quality Control

Our L-Propargylglycine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-Isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.