Description

α-Amanitin is a highly potent bicyclic octapeptide mycotoxin and a principal toxic constituent of the death cap mushroom (*Amanita phalloides*). Its profound biological significance lies in its specific and irreversible inhibition of RNA polymerase II, effectively halting mRNA synthesis in eukaryotic cells. This mechanism makes it an invaluable research-grade biochemical tool for studying transcription, apoptosis, and cell cycle dynamics. It is primarily utilized by researchers in biochemistry, molecular biology, and toxicology for experimental applications.

Application

• Biochemical Research: As a selective inhibitor of RNA polymerase II for studying transcription mechanisms and gene expression regulation.
• Cell Biology Studies: To induce apoptosis and investigate cell death pathways in various eukaryotic cell lines.
• Toxicology Research: As a reference standard for the analysis and detection of amatoxins in forensic and clinical samples.
• Drug Discovery: Used in screening assays to identify potential antidotes or protective agents against amatoxin poisoning.
• Academic & Pharmaceutical R&D: A critical reagent for fundamental research into polymerase function and the development of novel transcription-targeting therapies.

Basic Information

Product Name	α-Amanitin
CAS No.	23109-05-9
Molecular Formula	C39H54N10O14S
Molecular Weight	918.98 g/mol
Synonyms	α-Amanitin; Amanitin, α-; (3S,6S,9S,12R,15S,18S,21S,24R,30S,33S)-30-[(2R)-2-Butyl-3,4-dihydroxy-5-oxo-2H-pyrrol-2-yl]-33-[(1R)-1-hydroxyethyl]-3,6,9,12,15,18,21,24-octaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazatricyclo[28.3.0.014,18]tritriacontane-29-carboxylic acid; Amatoxin; NSC 213007; L-Amanitin
EINECS	Contact for details

Quality Control

Our α-Amanitin is produced and handled under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes batch-specific data on purity, related substances, and other critical parameters to ensure traceability and consistency for your research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.