Description

L-Ap4 CAS NO 23052-81-5 is a high-purity, biologically active glutamate analog used as a potent and selective agonist for group III metabotropic glutamate receptors (mGluRs). This compound is critical for neuroscience research, enabling the study of synaptic transmission, neural plasticity, and the pathophysiology of neurological disorders. It is an essential tool for pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on CNS-targeted therapeutics and advanced biochemical assays.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and modulation of group III mGlu receptors (mGlu4, mGlu6, mGlu7, mGlu8) in synaptic signaling.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and target validation assays for developing novel therapeutics targeting Parkinson's disease, anxiety, pain, and other CNS disorders.
• Academic & Institutional Research: Employed in university and government labs for fundamental research into neural circuits, neurotransmitter systems, and mechanisms of neuroprotection.
• Diagnostic Reagent Manufacturing: Serves as a reference standard or active component in the development of diagnostic kits and assays for neurological conditions.
• Biochemical Pathway Analysis: Used to investigate glutamate-mediated signal transduction pathways and their role in cellular physiology and disease states.

Basic Information

Product Name	L-Ap4
CAS No.	23052-81-5
Molecular Formula	C5H8NO6P
Molecular Weight	209.09 g/mol
Synonyms	L-2-Amino-4-phosphonobutyric acid; L-AP4; (S)-2-Amino-4-phosphonobutanoic acid; L-2-Amino-4-phosphonobutanoate; AP4; L-APB; L-2-Amino-4-phosphono-butanoic acid; Glutamate receptor agonist L-AP4
EINECS	Contact for details

Quality Control

Our L-Ap4 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.