Description

4-Hydroxy-D-(-)-2-Phenylglycine is a high-purity, non-proteinogenic amino acid derivative that serves as a critical chiral building block in organic synthesis. Its primary value lies in its role as a key intermediate for the production of advanced pharmaceutical compounds, particularly β-lactam antibiotics. This product is essential for manufacturers and R&D teams in the pharmaceutical, fine chemical, and biotechnology sectors who require a reliable source of high-quality chiral intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the synthesis of semi-synthetic β-lactam antibiotics, including certain cephalosporins and penicillins.
• Fine Chemical Synthesis: Used as a building block for the preparation of more complex chiral molecules, peptides, and peptidomimetics in research and development.
• Biocatalyst & Enzyme Substrate: Employed in enzymatic studies and as a substrate for specific enzymes involved in amino acid metabolism research.
• Asymmetric Synthesis: Utilized in catalytic asymmetric reactions to introduce chirality into target molecules for agrochemicals or advanced materials.

Basic Information

Product Name	4-Hydroxy-D-(-)-2-Phenylglycine
CAS No.	22818-40-2
Molecular Formula	C8H9NO3
Molecular Weight	167.16 g/mol
Synonyms	D-4-Hydroxyphenylglycine; (R)-2-Amino-2-(4-hydroxyphenyl)acetic acid; D-(-)-p-Hydroxyphenylglycine; (R)-4-Hydroxyphenylglycine; D-HPG; HPG; D-p-Hydroxyphenylglycine; (R)-Amino(4-hydroxyphenyl)acetic acid
EINECS	245-247-0

Quality Control

Our 4-Hydroxy-D-(-)-2-Phenylglycine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles are available upon request, supporting compliance with cGMP and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.