Description

Proline, 2-Hydroxy-1-Methyl-5-Oxo- (8Ci,9Ci) CAS NO 22671-35-8 is a specialized proline derivative, a heterocyclic amino acid analog of significant interest in advanced organic synthesis and pharmaceutical research. This compound matters for its role as a key chiral building block and intermediate in the development of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules. It is primarily needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers focused on peptidomimetics, prodrug synthesis, and the creation of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel APIs, particularly in oncology and metabolic disease research.
• Peptidomimetics & Drug Design: Used to construct modified peptide backbones to enhance stability, bioavailability, and receptor selectivity of drug candidates.
• Asymmetric Synthesis: Serves as a versatile starting material or auxiliary in stereoselective catalytic reactions.
• Biochemical Research: Employed in studies of enzyme inhibition, substrate specificity, and metabolic pathway analysis.
• Prodrug Development: Utilized to design and synthesize prodrug forms to improve the pharmacokinetic profiles of therapeutic compounds.
• Fine Chemical Synthesis: An intermediate for the production of specialty chemicals, complex natural product analogs, and advanced materials.

Basic Information

Product Name	Proline, 2-Hydroxy-1-Methyl-5-Oxo- (8Ci,9Ci)
CAS No.	22671-35-8
Molecular Formula	C6H9NO3
Molecular Weight	143.14 g/mol
Synonyms	2-Hydroxy-1-methyl-5-oxopyrrolidine-2-carboxylic acid; 1-Methyl-5-oxoproline; 2-Hydroxy-1-methyl-5-oxoproline; 1-Methyl-2-hydroxy-5-oxoproline; 5-Oxo-1-methylproline; 2-Hydroxy-1-methylpyrrolidine-5-carboxylic acid; (2S)-2-Hydroxy-1-methyl-5-oxopyrrolidine-2-carboxylic acid (for the S-enantiomer); L-1-Methyl-5-oxoproline
EINECS	Contact for details

Quality Control

Our Proline, 2-Hydroxy-1-Methyl-5-Oxo- (8Ci,9Ci) is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.