Description

2-Chloro-5-Methylpyrimidine is a versatile halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its reactive chlorine atom enables precise molecular modifications. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of various drug candidates, particularly kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and plant growth regulators.
• Chemical Research: Serves as a versatile scaffold for medicinal chemistry and process development in R&D laboratories.
• Material Science: A building block for creating functionalized polymers and advanced organic materials.
• Cross-Coupling Reactions: Acts as an electrophilic partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleoside Analog Development: Used in the research and synthesis of modified nucleosides and nucleotides.

Basic Information

Product Name	2-Chloro-5-Methylpyrimidine
CAS No.	22536-61-4
Molecular Formula	C5H5ClN2
Molecular Weight	128.56 g/mol
Synonyms	5-Methyl-2-chloropyrimidine; 2-Chloro-5-methylpyrimidine; 2-Chloro-5-methyl-1,3-diazine; 5-Methyl-2-pyrimidinyl chloride; 2-Chloro-5-methyl-pyrimidine; 22536-61-4; 2-Chloro-5-methyl-1,3-diazabenzene
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methylpyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including HPLC, GC, and NMR, to meet the stringent requirements of pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.