Description

2-Chloro-4-ethylthio-5-fluoropyrimidine is a high-value fluorinated pyrimidine building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogen and sulfur substituents enable precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluoropyrimidine motifs into novel compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated nucleoside analogs and other potential therapeutic agents, including antiviral and anticancer candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluoropyrimidine core.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and the exploration of new chemical entities.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific advanced intermediates under cGMP conditions where required.
• Material Science Precursor: Investigated for the synthesis of specialized ligands or functional molecules used in catalysis or advanced materials.

Basic Information

Product Name	2-Chloro-4-ethylthio-5-fluoropyrimidine
CAS No.	22462-40-4
Molecular Formula	C6H6ClFN2S
Molecular Weight	192.64 g/mol
Synonyms	5-Fluoro-2-chloro-4-(ethylthio)pyrimidine; 4-Ethylthio-2-chloro-5-fluoropyrimidine; 2-Chloro-5-fluoro-4-(ethylthio)pyrimidine; 2-Chloro-4-(ethylsulfanyl)-5-fluoropyrimidine; 5-Fluoro-2-chloro-4-ethylsulfanylpyrimidine; 22462-40-4; Fluoropyrimidine intermediate
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-ethylthio-5-fluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.