Description

2(1H)-Pyrimidinone, 4-Chloro-5-Fluoro- (8Ci,9Ci) is a high-value halogenated pyrimidinone derivative, serving as a critical building block in advanced organic synthesis. Its precise molecular architecture makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for creating compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in antiviral and anticancer therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for enhanced activity.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the synthesis chain for final API production under controlled GMP environments.
• Material Science Precursor: Potential use in the synthesis of specialized organic materials and ligands for catalysis.

Basic Information

Product Name	2(1H)-Pyrimidinone, 4-Chloro-5-Fluoro- (8Ci,9Ci)
CAS No.	22462-34-6
Molecular Formula	C4H2ClFN2O
Molecular Weight	148.52 g/mol
Synonyms	4-Chloro-5-fluoropyrimidin-2(1H)-one; 4-Chloro-5-fluoro-2-hydroxypyrimidine; 5-Fluoro-4-chloropyrimidin-2-ol; 4-Chloro-5-fluoro-1H-pyrimidin-2-one; 4-Chloro-5-fluoro-2(1H)-pyrimidinone; 4-Chloro-5-fluorouracil (common misnomer, related structure); 2-Hydroxy-4-chloro-5-fluoropyrimidine
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-5-fluoropyrimidin-2(1H)-one adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.