Description

(R)-Thiamylal is the single enantiomer of the short-acting barbiturate derivative thiamylal. This specific stereoisomer is of significant interest in pharmaceutical research and development for studying structure-activity relationships and potential enantioselective effects. It is primarily utilized as a key chiral intermediate or reference standard in the synthesis and analytical characterization of advanced pharmaceutical compounds. Target users include research institutions, analytical laboratories, and pharmaceutical companies engaged in neuropharmacology, anesthetic development, and chiral chemistry.

Application

• Pharmaceutical Reference Standard: Used as a high-purity chiral standard for analytical method development and validation in HPLC, GC, and LC-MS systems.
• Chiral Intermediate: Serves as a critical building block in the enantioselective synthesis of novel barbiturate-based compounds for pharmacological evaluation.
• Biochemical Research: Employed in neuroscience and pharmacology studies to investigate the stereospecific binding and activity at GABAA receptors.
• Quality Control: Acts as an impurity marker or system suitability standard in the quality control testing of related pharmaceutical substances.
• Metabolite Studies: Used in the research of drug metabolism and pharmacokinetics (DMPK) to understand the fate of thiamylal enantiomers.

Basic Information

Product Name	(R)-Thiamylal
CAS No.	22328-96-7
Molecular Formula	C12H18N2O2S
Molecular Weight	254.35 g/mol
Synonyms	(R)-Thiamylal; (5R)-5-(1-Methylbutyl)-5-(2-thienyl)-2-thiobarbituric acid; (R)-5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid; (R)-Enantiomer of Thiamylal; (+)-Thiamylal; R-Thiamylal; NSC 401443; Thiamylal (R-isomer)
EINECS	Contact for details

Quality Control

Our (R)-Thiamylal is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, enantiomeric excess (ee) determination, and identification by spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.