Description

4-(Difluoromethoxy)Aniline is a specialized aromatic amine derivative featuring a difluoromethoxy substituent, serving as a critical building block in advanced organic synthesis. This compound matters for its role in introducing fluorine-containing motifs, which are highly sought after to modulate the physicochemical and biological properties of target molecules. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS, anti-inflammatory, or anti-infective therapies.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorine-containing liquid crystals for display technologies.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique solubility, thermal stability, or surface properties.
• Organic Electronic Materials: Utilized in the research and development of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research & Development: A versatile reagent for academic and industrial research in fluorine chemistry and novel heterocycle formation.

Basic Information

Product Name	4-(Difluoromethoxy)Aniline
CAS No.	22236-10-8
Molecular Formula	C7H7F2NO
Molecular Weight	159.13 g/mol
Synonyms	4-Aminophenyl difluoromethyl ether; 1-Amino-4-(difluoromethoxy)benzene; p-(Difluoromethoxy)aniline; 4-(Difluoromethoxy)benzenamine; Aniline, 4-(difluoromethoxy)-; DFMA; Difluoromethoxybenzene-4-amine
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Aniline is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This amine derivative should be kept under an inert atmosphere for long-term storage to minimize the risk of oxidation and discoloration.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.