Description

3-(Difluoromethoxy)Aniline is a specialized aromatic amine derivative featuring a difluoromethoxy substituent, serving as a critical building block in advanced organic synthesis. Its unique fluorinated structure imparts desirable properties such as enhanced metabolic stability and lipophilicity to target molecules, making it a high-value intermediate. This compound is primarily sought by R&D and production teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the research and production of active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated motifs for improved drug efficacy and stability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the difluoromethoxy group can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifiers: Incorporated into specialty polymers to alter physical properties such as chemical resistance, thermal stability, and surface characteristics.
• Dye & Pigment Manufacturing: Acts as an intermediate in the production of complex, high-performance dyes and pigments.
• Cross-Coupling Reactions: Utilized as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to construct complex nitrogen-containing architectures.

Basic Information

Product Name	3-(Difluoromethoxy)Aniline
CAS No.	22236-08-4
Molecular Formula	C7H7F2NO
Molecular Weight	159.13 g/mol
Synonyms	3-(Difluoromethoxy)benzenamine; m-(Difluoromethoxy)aniline; 3-Aminophenyl difluoromethyl ether; Benzenamine, 3-(difluoromethoxy)-; 3-Difluoromethoxyaniline; Aniline, 3-(difluoromethoxy)-; 22236-08-4; 3-(Difluoromethoxy)phenylamine
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong oxidizing agents and acids. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.