Description

2-(Difluoromethoxy)Aniline is a specialized aromatic amine derivative featuring a difluoromethoxy substituent, which imparts unique electronic and steric properties critical for advanced chemical synthesis. This compound serves as a high-value pharmaceutical intermediate and agrochemical building block, enabling the development of novel active ingredients with enhanced efficacy and stability. It is essential for R&D and production teams in the life sciences and fine chemical sectors seeking to innovate in drug discovery and crop protection formulations.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances biological activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Serves as a precursor for specialty chemicals used in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Dye & Pigment Manufacturing: Intermediate for creating specialized azo dyes and pigments with improved color fastness and solubility properties.
• Polymer Modification: Used to introduce fluorine-containing groups into polymer chains, altering surface properties, chemical resistance, and thermal stability.
• Research & Development: Valuable reagent in academic and industrial R&D for exploring new fluorinated compounds and reaction pathways in medicinal and materials chemistry.

Basic Information

Product Name	2-(Difluoromethoxy)Aniline
CAS No.	22236-04-0
Molecular Formula	C7H7F2NO
Molecular Weight	159.13 g/mol
Synonyms	2-Amino(difluoromethoxy)benzene; o-(Difluoromethoxy)aniline; 1-Amino-2-(difluoromethoxy)benzene; Benzenamine, 2-(difluoromethoxy)-; 2-(Difluoromethoxy)phenylamine; Difluoromethoxy-2-aniline; 2-(Difluoromethoxy)benzenamine
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.