Description

4-(6-Chloropyrimidin-4-Yl)Morpholine CAS NO 22177-92-0 is a high-purity, functionalized pyrimidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its unique heterocyclic structure, which is essential for constructing complex molecules with targeted biological and chemical properties. This intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a precursor for creating functional polymers, ligands for metal-organic frameworks (MOFs), and other advanced materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring precise functionalization of the pyrimidine core.

Basic Information

Product Name	4-(6-Chloropyrimidin-4-Yl)Morpholine
CAS No.	22177-92-0
Molecular Formula	C8H10ClN3O
Molecular Weight	199.64 g/mol
Synonyms	4-(6-Chloro-4-pyrimidinyl)morpholine; 6-Chloro-4-morpholin-4-ylpyrimidine; 4-Morpholino-6-chloropyrimidine; 6-Chloro-4-morpholinopyrimidine; 4-(6-Chloropyrimidin-4-yl)morpholine; Morpholine, 4-(6-chloro-4-pyrimidinyl)-; 22177-92-0; 4-(6-Chloropyrimidin-4-yl)morpholine
EINECS	Contact for details

Quality Control

Our 4-(6-Chloropyrimidin-4-Yl)Morpholine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliable batch-to-batch consistency for your development and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.