Description

Methohexital is a short-acting barbiturate derivative, widely recognized for its potent anesthetic and sedative properties. Its primary value lies in providing rapid induction of anesthesia with a relatively short duration of action, making it a critical agent in controlled medical settings. This compound is essential for pharmaceutical manufacturers, research institutions, and compounding pharmacies involved in developing and producing injectable anesthetic formulations.

Application

• Intravenous Anesthetic Agent: Primary use for the induction of general anesthesia in surgical and diagnostic procedures.
• Sedation in Intensive Care: Used for short-term sedation of mechanically ventilated patients in critical care settings.
• Electroconvulsive Therapy (ECT): Employed as an anesthetic to provide brief unconsciousness during ECT sessions.
• Veterinary Anesthesia: Application in veterinary medicine for the induction of anesthesia in various animal species.
• Pharmacological Research: Serves as a reference standard and active pharmaceutical ingredient (API) in neuroscience and anesthesiology research.
• Compounding Pharmacy: Used by specialized pharmacies to prepare tailored anesthetic solutions where commercial formulations are not suitable.

Basic Information

Product Name	Methohexital
CAS No.	22151-68-4
Molecular Formula	C14H18N2O3
Molecular Weight	262.30 g/mol
Synonyms	Methohexitone; 1-Methyl-5-(1-methyl-2-pentyn-1-yl)-5-(2-propen-1-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione; Brevital; Brietal; Methohexital Sodium (salt form); Enallynymal; Methylhexobital; A-1770
EINECS	244-785-7

Quality Control

Our Methohexital is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.