Description

1-(1-L-Alanyl-L-Prolyl)-L-Proline is a synthetic tripeptide derivative of significant interest in pharmaceutical and biochemical research. This compound serves as a key intermediate and a model substrate for studying enzymatic processes, particularly those involving proline-specific peptidases. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in proteomics, drug discovery, and the synthesis of more complex bioactive peptides.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel peptide-based therapeutics and prodrugs.
• Biochemical Research: Used as a specific substrate for studying the activity and inhibition of enzymes like prolyl oligopeptidase (POP) and dipeptidyl peptidase IV (DPP-IV).
• Proteomics & Enzymology: Employed in assays to understand protein degradation pathways and enzyme kinetics related to proline metabolism.
• Reference Standard: Serves as a high-purity analytical standard for quality control in peptide manufacturing and research.
• Drug Discovery: Investigated for its potential role in developing treatments for neurological disorders and metabolic diseases.
• Fine Chemical Synthesis: A specialized intermediate for constructing complex molecular architectures in advanced organic chemistry.

Basic Information

Product Name	1-(1-L-Alanyl-L-Prolyl)-L-Proline
CAS No.	22049-75-8
Molecular Formula	C16H24N4O5
Molecular Weight	352.39 g/mol
Synonyms	Ala-Pro-Pro; L-Alanyl-L-prolyl-L-proline; APP; 1-(1-L-Alanyl-L-prolyl)-L-proline; H-Ala-Pro-Pro-OH; Tripeptide Ala-Pro-Pro; AP Proline; N-(N-L-Alanyl-L-prolyl)-L-proline; (S)-1-((S)-1-((S)-2-Aminopropanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(1-L-Alanyl-L-Prolyl)-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	Specific range available on COA
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.