Description

n-Acetyl-3,5-Diiodo-L-Tyrosine Ethyl Ester is a chemically modified derivative of the amino acid L-tyrosine, featuring acetylation, diiodination, and ethyl ester functional groups. This compound is a critical synthetic intermediate for the development of high-value pharmaceutical and biochemical agents, particularly in thyroid hormone research and diagnostic applications. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers requiring a reliable and high-purity building block for complex organic synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of thyroid hormone analogs and related bioactive molecules.
• Biochemical Research: Used as a substrate or reference standard in enzymatic studies and metabolic pathway investigations.
• Radiopharmaceutical Development: Acts as a starting material for the synthesis of iodine-labeled compounds used in medical imaging and diagnostics.
• Peptide Synthesis: Employed as a protected tyrosine derivative in the solid-phase or solution-phase synthesis of specialized peptides.
• Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control of related substances.
• Organic Synthesis Building Block: Provides a versatile scaffold for further chemical modifications in medicinal chemistry programs.

Basic Information

Product Name	n-Acetyl-3,5-Diiodo-L-Tyrosine Ethyl Ester
CAS No.	21959-36-4
Molecular Formula	C₁₃H₁₅I₂NO₄
Molecular Weight	503.07 g/mol
Synonyms	N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester; Ethyl N-acetyl-3,5-diiodo-L-tyrosinate; L-Tyrosine, N-acetyl-3,5-diiodo-, ethyl ester; 3,5-Diiodo-N-acetyl-L-tyrosine ethyl ester; ADITE; Ac-Diiodo-Tyr-OEt; (2S)-2-Acetamido-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid ethyl ester
EINECS	Contact for details

Quality Control

Our n-Acetyl-3,5-Diiodo-L-Tyrosine Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.