Description

Z-His(Bzl)-OH is a protected derivative of the essential amino acid L-Histidine, where the imidazole side chain is protected by a benzyl (Bzl) group. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of histidine into complex peptide sequences. It is primarily utilized by pharmaceutical researchers, peptide manufacturers, and biotechnology companies developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of peptides containing histidine residues.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting various diseases.
• Bioconjugation and Labeling: Serves as an intermediate for attaching labels, tags, or other molecules to peptides via the histidine side chain.
• Enzyme Mimic and Catalyst Research: Employed in the study of metalloenzymes and the design of synthetic catalysts due to the metal-coordinating ability of histidine.
• Biochemical Research Reagent: Used as a standard or intermediate in analytical methods and metabolic studies.

Basic Information

Product Name	Z-His(Bzl)-OH
CAS No.	21929-66-8
Molecular Formula	C20H21N3O4
Molecular Weight	367.40 g/mol
Synonyms	Nα-Carboxybenzyl-Nim-benzyl-L-histidine; Z-Nim-Benzyl-L-histidine; CBZ-His(Bzl)-OH; Nα-Cbz-Nim-Bzl-L-histidine; Benzyl N-[(benzyloxy)carbonyl]-L-histidinate; (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-(1-benzylimidazol-4-yl)propanoic acid; Z-L-Histidine(Nim-benzyl)-OH
EINECS	Contact for details

Quality Control

Our Z-His(Bzl)-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR). We provide Certificates of Analysis (COA) with each shipment, detailing all specifications to ensure the material meets the stringent requirements for peptide synthesis and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-10.0° to -14.0° (c=1 in AcOH)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.