Description

H-Pro-Pro-Pro-Pro-OH is a synthetic tetrapeptide composed of four consecutive proline residues. This unique, rigid polyproline structure is of significant interest in biochemical and pharmaceutical research for studying protein folding, collagen mimics, and peptide-based materials. It serves as a critical building block and model compound for researchers and manufacturers in the life sciences sector.

Application

• Biochemical Research: Used as a model peptide for studying polyproline helix (PPII) conformation, protein folding dynamics, and peptide stability.
• Pharmaceutical Development: Acts as a key intermediate or structural motif in the synthesis of more complex therapeutic peptides and peptidomimetics.
• Material Science: Investigated for creating bio-inspired materials, hydrogels, and scaffolds due to the rigid, rod-like structure of polyproline sequences.
• Enzyme Substrate & Inhibitor Studies: Serves as a substrate for proline-specific enzymes like prolyl oligopeptidase or as a component in inhibitor design.
• Standards & Calibration: Utilized as a high-purity reference standard in analytical chromatography (HPLC, LC-MS) for peptide analysis.
• Cosmeceutical Research: Explored in skincare research for its potential role in collagen synthesis and stabilization.

Basic Information

Product Name	H-Pro-Pro-Pro-Pro-OH
CAS No.	21866-90-0
Molecular Formula	C20H30N4O5
Molecular Weight	406.48 g/mol
Synonyms	Pro-Pro-Pro-Pro; Polyproline (n=4); L-Prolyl-L-prolyl-L-prolyl-L-proline; H-Pro-Pro-Pro-Pro-OH Tetrapeptide; (Pro)4; Tetrakis(proline); Proline Tetramer; L-Proline Homotetramer; 21866-90-0
EINECS	Contact for details

Quality Control

Our H-Pro-Pro-Pro-Pro-OH is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.