Description

o-Phospho-L-Tyrosine is a phosphorylated derivative of the amino acid L-tyrosine, serving as a critical biochemical tool in signal transduction research. This compound is essential for studying tyrosine kinase and phosphatase activity, which are fundamental to cellular regulation and numerous disease pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery, biochemical assay development, and as a reference standard.

Application

• Biochemical Research: A key substrate and standard for studying protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) in cell signaling pathways.
• Pharmaceutical Development: Used in high-throughput screening (HTS) assays to identify and characterize potential kinase inhibitor drugs for cancer and other diseases.
• Enzyme Kinetics: Employed to determine kinetic parameters (Km, Vmax) and inhibition constants (Ki) for tyrosine-specific enzymes.
• Diagnostic Reagents: Serves as a component in diagnostic kits and reagents designed to detect kinase activity or related biomarkers.
• Cell Biology Studies: Used to investigate the role of tyrosine phosphorylation in cellular processes like growth, differentiation, and apoptosis.
• Reference Standard: Acts as a high-purity analytical standard for HPLC, LC-MS, and NMR to qualify other reagents or quantify phosphorylation in samples.

Basic Information

Product Name	o-Phospho-L-Tyrosine
CAS No.	21820-51-9
Molecular Formula	C9H12NO6P
Molecular Weight	261.17 g/mol
Synonyms	L-O-Phosphotyrosine; Phosphotyrosine; O4-Phospho-L-tyrosine; (2S)-2-Amino-3-(4-phosphonoxyphenyl)propanoic acid; p-Tyrosine-O-phosphate; L-Tyrosine O-phosphate; L-Tyrosine, O-phosphate-; Tyrosine phosphate; PTyr
EINECS	244-596-7

Quality Control

Our o-Phospho-L-Tyrosine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.