Description

H-Tyr-Gly-Gly-Oh CAS NO 21778-69-8 is a synthetic tripeptide derivative, specifically the C-terminal carboxylic acid form of the sequence Tyrosine-Glycine-Glycine. This compound serves as a crucial building block (amino acid derivative) and biochemical research tool for studying peptide structure-activity relationships and enzyme interactions. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions engaged in peptide synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Biochemical Research: Serves as a standard, reference material, or precursor in studies of enzyme kinetics, substrate specificity, and metabolic pathways.
• Peptide Synthesis: Acts as a key fragment in solid-phase or solution-phase synthesis of longer, more complex peptide chains for biological evaluation.
• Neuroscience Research: Employed in investigations related to neuropeptide analogs and their potential effects on receptor binding and signal transduction.
• Academic & Contract Research: Essential for university laboratories and CROs (Contract Research Organizations) conducting fundamental and applied life science research.

Basic Information

Product Name	H-Tyr-Gly-Gly-Oh
CAS No.	21778-69-8
Molecular Formula	C₁₄H₁₉N₃O₅
Molecular Weight	309.32 g/mol
Synonyms	L-Tyrosylglycylglycine; Tyr-Gly-Gly; TGG; H-Tyr-Gly-Gly-OH; N-(2-{2-[(2S)-2-Amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetic acid; Tyrosine-Glycine-Glycine; YGG; (S)-2-Amino-3-(4-hydroxyphenyl)-N-(2-(2-aminoacetamido)ethyl)propanamide (carboxylic acid form)
EINECS	Contact for details

Quality Control

Our H-Tyr-Gly-Gly-Oh is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for that lot. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.