Description

2-Hydroxyethylvaline is a specialized non-proteinogenic amino acid derivative, valued for its role as a key chiral building block in advanced organic synthesis. Its structural features make it a critical intermediate for the development of pharmaceuticals, particularly in the synthesis of complex active pharmaceutical ingredients (APIs) and peptide mimetics. This high-purity compound is essential for research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors seeking reliable, high-quality intermediates for their most demanding synthesis projects.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, including protease inhibitors and other biologically active molecules.
• Peptide Chemistry: Used in the preparation of modified peptides and peptidomimetics to enhance stability, bioavailability, or biological activity.
• Asymmetric Synthesis: Serves as a valuable starting material or auxiliary in stereoselective chemical reactions to construct complex molecular architectures.
• Bioconjugation & Linker Chemistry: Its functional groups allow for its use in creating chemical linkers for antibody-drug conjugates (ADCs) or other bioconjugation strategies.
• Biochemical Research: Employed in metabolic studies and as a standard or reagent in analytical and biochemical research laboratories.
• Fine Chemical Production: An intermediate in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	2-Hydroxyethylvaline
CAS No.	21768-51-4
Molecular Formula	C7H15NO3
Molecular Weight	161.20 g/mol
Synonyms	L-2-Hydroxyethylvaline; (2S)-2-Amino-3-methyl-4-hydroxybutanoic Acid; 4-Hydroxy-L-isoleucine (Note: This is a common but not strictly accurate synonym based on structure); 2-Amino-3-methyl-4-hydroxybutyric Acid; H-HoeVal-OH; 2-Hydroxyethyl-L-valine; β-Hydroxy-L-isoleucine; (S)-2-Amino-3-methyl-4-hydroxybutanoic Acid
EINECS	Contact for details

Quality Control

Our 2-Hydroxyethylvaline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including chiral purity and impurity profile analysis via HPLC. A Certificate of Analysis (COA) is supplied with each batch, detailing specifications for identity, assay, optical rotation, and related substances. Our quality standards are designed to meet the rigorous demands of cGMP and pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Optical Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.