Description

H-Gln-Nh2 Hcl CAS NO 21752-29-4 is a protected derivative of the amino acid glutamine, specifically the hydrochloride salt of glutamine amide. This compound is a crucial building block in peptide synthesis, offering a protected side chain that prevents unwanted reactions during the coupling process. It is primarily utilized by pharmaceutical researchers, peptide chemists, and fine chemical manufacturers involved in developing therapeutic peptides, bioactive compounds, and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of glutamine into peptide chains, preventing side reactions at the amide group.
• Solution-Phase Peptide Synthesis: Used in classical peptide coupling strategies for research-scale and industrial-scale production of custom peptides.
• Pharmaceutical Intermediate: Serves as a critical raw material in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Employed in studies of protein structure-function relationships and the development of enzyme inhibitors or receptor agonists/antagonists.
• Fine Chemical Synthesis: Acts as a chiral synthon for constructing more complex molecules in medicinal chemistry and asymmetric synthesis.
• Cosmetic Peptide Production: Used in the manufacture of specialized peptides for cosmetic and dermatological applications.

Basic Information

Product Name	H-Gln-Nh2 Hcl
CAS No.	21752-29-4
Molecular Formula	C5H12N3O2 • HCl
Molecular Weight	197.63 g/mol
Synonyms	L-Glutamine amide hydrochloride; H-Gln-NH2•HCl; Glutaminamide hydrochloride; (S)-2-Amino-4-carbamoylbutanoic acid hydrochloride; 2-Amino-4-carbamoylbutyric acid hydrochloride; Fmoc-Gln(Trt)-OH precursor; Glutamine side-chain protected derivative; Gln-NH2 HCl
EINECS	Contact for details

Quality Control

Our H-Gln-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with full traceability are provided for every shipment. We can supply material compliant with cGMP standards for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent decomposition. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Assay (Titration)	98.0 - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.