Description

Etifoxine is a non-benzodiazepine anxiolytic agent with a distinct pharmacological profile, offering a valuable alternative in neuropharmacological research and development. Its primary value lies in its ability to modulate GABAergic transmission through interaction with translocator protein (TSPO), which is of significant interest for studying novel pathways in anxiety and stress-related disorders. This compound is essential for pharmaceutical R&D teams, academic researchers, and reference standard producers focused on central nervous system (CNS) drug discovery and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for quality control and analytical method validation in drug manufacturing.
• Neuropharmacology Research: A key tool compound for in vitro and in vivo studies investigating TSPO-mediated neurosteroidogenesis and its anxiolytic effects.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical synthetic intermediate in the production of finished dosage forms for clinical studies.
• Mechanistic Studies: Employed to explore and differentiate GABAergic mechanisms from classical benzodiazepines, aiding in the development of drugs with improved safety profiles.
• Analytical Development: Utilized for developing and calibrating HPLC, LC-MS, and other chromatographic assays in bioanalytical and pharmacokinetic studies.

Basic Information

Product Name	Etifoxine
CAS No.	21715-46-8
Molecular Formula	C17H17ClN2O
Molecular Weight	300.78 g/mol
Synonyms	Etifoxin; HOE 36-801; 6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine; Stresam; 2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine
EINECS	Contact for details

Quality Control

Our Etifoxine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other validated methods, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.